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Fine specificities of anti-LM1 IgG antibodies in Guillain-Barré syndrome.

AbstractWe investigated the prevalence of anti-LM1 IgG antibody and its fine specificity in Guillain-Barré syndrome (GBS). Anti-LM1 IgG and IgM antibodies from sera of 47 patients with GBS--19 with acute inflammatory demyelinating polyneuropathy (AIDP), 27 with acute motor axonal neuropathy (AMAN), and 1 with acute motor-sensory axonal neuropathy (AMSAN)--were tested. Anti-LM1 IgG antibody was detected in only one patient with AIDP, whereas it was present in seven with AMAN and in one with AMSAN. Sera from the eight IgG anti-LM1-positive patients with AMAN/AMSAN also had IgG activity against the gangliosides GM1, GM1b, GD1a, GalNAc-GD1a, GD1b, or GQ1b. Anti-LM1 IgG antibodies from the AMAN/AMSAN patients cross-reacted with other gangliosides, whereas IgG antibody from the AIDP patient was monospecific against LM1. Anti-LM1 IgG antibody therefore, cannot be a marker of AIDP. In addition, whether monospecific anti-LM1 IgG antibody is associated with AIDP remains to be concluded. Larger studies are needed to verify whether monospecific anti-LM1 IgG antibody could be a marker of AIDP.
AuthorsKeiichiro Susuki, Nobuhiro Yuki, Koichi Hirata, Satoshi Kuwabara (Affiliation: Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, 321-0293, Tochigi, Japan.)
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 195 Issue 2 Pg. 145-8 (Mar 30 2002) ISSN: 0022-510X [Print] Netherlands
PMID11897245 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biological Markers
  • Gangliosides
  • Immunoglobulin G
  • LM1 ganglioside
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibody Specificity (immunology)
  • Axons (immunology, pathology)
  • Biological Markers (blood)
  • Central Nervous System (immunology, physiopathology)
  • Female
  • Gangliosides (immunology)
  • Guillain-Barre Syndrome (blood, diagnosis, immunology)
  • Humans
  • Immunoglobulin G (blood, immunology)
  • Male
  • Middle Aged
  • Motor Neurons (immunology, pathology)

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