Genetic susceptibility in Dupuytren's disease: lack of association of a novel transforming growth factor beta(2) polymorphism in Dupuytren's disease.

Abstract

The genes involved in the pathogenesis of Dupuytren's disease have yet to be identified. In this study, we tested for an association between Dupuytren's disease (DD) and a novel insertion polymorphism within the 5'-untranslated region (5'-UTR), of the TGFbeta(2) gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFbeta(2) allele frequency distributions between cases and controls for the TGFbeta(2) polymorphism.

• Authors: A Bayat, A Alansar, A H Hajeer, M Shah, J S Watson, J K Stanley, M W J Ferguson, W E R Ollier
• Journal: Journal of hand surgery (Edinburgh, Scotland) (J Hand Surg Br) Vol. 27 Issue 1 Pg. 47-9 (Feb 2002) ISSN: 0266-7681 [Print] Scotland
• PMID: 11895345 (Publication Type: Journal Article)
• Copyright: Copyright 2002 The British Society for Surgery of the Hand.

Chemical References

• TGFB2 protein, human
• Transforming Growth Factor beta
• Transforming Growth Factor beta2

Topics

• Adult
• Aged
• Aged, 80 and over
• Chi-Square Distribution
• Dupuytren Contracture (genetics)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Transforming Growth Factor beta (genetics)
• Transforming Growth Factor beta2