HLA-DRB3*0101 is associated with Graves' disease in Jamaicans.

Abstract

OBJECTIVES:

Graves' disease is associated with different human leucocyte antigen (HLA) genes in different populations. This studywasdesigned to examinethe HLA class II associations with Graves' disease in Jamaicans.

PATIENTS:

One hundred and six Jamaicans with Graves' disease and 104 controls.

DESIGN:

Oligotyping for HLA-DRB1, DRB3, DQA1 and DQB1 alleles was performed using the polymerase chain reaction sequence specific oligonucleotide probe (PCR-SSOP) technique. RESULTS The frequency of HLA-DRB3 *0101 was increased significantly in the patients compared to controls (38.7% vs. 19.2%; RR = 2.72; Pc < 0.015). The protective alleles for Graves' disease were DRB1 *0901 (0.9% vs. 20.2%; RR = 0.04; Pc < 0.001), DRB1*1001 (0.0% vs. 11%; RR = 0.0%; Pc < 0.01) and DRB4 *0101 (0.0% vs. 12.5%; RR = 0.0; Pc < 0.05). A high female to male ratio of Graves' disease, 25 :1, was observed. Other associated autoimmune diseases were rare and no significant HLA class II associations were found with clinical markers of disease.

CONCLUSIONS:

Jamaican patients with Graves' disease share the DRB3 *0101 susceptible allele and the DRB4 *01 protective allele but not the susceptible haplotype DRB1 *0301, DRB3*0101, DQA1*0501 with Caucasians.

• Authors: M F Smikie, R W Pascoe, E Barton, O Morgan, N Christian, G Dowe, K Roye-Green, V Bailey, O James
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 55 Issue 6 Pg. 805-8 (Dec 2001) ISSN: 0300-0664 [Print] England
• PMID: 11895223 (Publication Type: Journal Article)

Chemical References

• HLA-DQ Antigens
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• HLA-DQA1 antigen
• HLA-DQB1 antigen
• HLA-DR Antigens
• HLA-DRB1 Chains
• HLA-DRB1*03:01 antigen
• HLA-DRB3 Chains

Topics

• Adolescent
• Adult
• Aged
• Black People
• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• Graves Disease (ethnology, genetics)
• HLA-DQ Antigens (genetics)
• HLA-DQ alpha-Chains
• HLA-DQ beta-Chains
• HLA-DR Antigens (genetics)
• HLA-DRB1 Chains
• HLA-DRB3 Chains
• Humans
• Jamaica (ethnology)
• Male
• Middle Aged