Granulocyte macrophage-colony stimulating factor and oral mucositis.

Abstract

OBJECTIVE:

To evaluate the effect of granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with oral mucositis.

DATA SOURCES:

Literature was accessed through MEDLINE (1966-June 2000) and bibliographic searches.

DATA SYNTHESIS:

Published literature assessing the use of GM-CSF to treat or prevent oral mucositis was analyzed.

CONCLUSIONS:

Reports of GM-CSF improving mucositis have been published; however, because of limitations in these reports, insufficient evidence confirms the benefits of GM-CSF. These preliminary studies provide a rationale to conduct well-designed, double-blind, randomized trials to evaluate the safety and efficacy of GM-CSF in the treatment and/or prevention of oral mucositis induced by chemotherapy and/or radiotherapy.

• Authors: Stacey M Fung, Mary J Ferrill
• Journal: The Annals of pharmacotherapy (Ann Pharmacother) Vol. 36 Issue 3 Pg. 517-20 (Mar 2002) ISSN: 1060-0280 [Print] United States
• PMID: 11895067 (Publication Type: Journal Article, Review)

Chemical References

• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Granulocyte-Macrophage Colony-Stimulating Factor (physiology, therapeutic use)
• Humans
• Mouth Mucosa (drug effects)
• Randomized Controlled Trials as Topic
• Severity of Illness Index
• Stomatitis (classification, drug therapy, prevention & control)