Abstract |
Radioisotope-labelled lipiodol has been used in the therapy of liver cancer. Recently a lipiodol solution of 188Re-labelled diaminedithiol (DD) has been reported to show a high uptake in the liver cancer. We synthesized long-chain alkyl DD derivatives to improve their uptake and retention in tissue. As the length of the alkyl chain increased, tissue uptake and retention also increased due to hydrophobic interaction with lipiodol. Among the synthesized compounds, the lipiodol solution of 188Re-HDD, the DD derivative with the longest side chain (C16), is a promising agent for therapy of liver cancer.
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Authors | Y-S Lee, J M Jeong, Y J Kim, J W Chung, J H Park, Y-G Suh, D S Lee, J-K Chung, M C Lee |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 23
Issue 3
Pg. 237-42
(Mar 2002)
ISSN: 0143-3636 [Print] England |
PMID | 11891481
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organometallic Compounds
- Radiopharmaceuticals
- rhenium diaminedithiol
- Iodized Oil
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Topics |
- Animals
- Humans
- Iodized Oil
(pharmacokinetics)
- Liver Neoplasms
(metabolism, radiotherapy)
- Lung
(metabolism)
- Mice
- Mice, Inbred ICR
- Organometallic Compounds
(chemical synthesis, pharmacokinetics, therapeutic use)
- Radiopharmaceuticals
(chemical synthesis, pharmacokinetics, therapeutic use)
- Tissue Distribution
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