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Synthesis of 188 Re-labelled long chain alkyl diaminedithiol for therapy of liver cancer.

Abstract
Radioisotope-labelled lipiodol has been used in the therapy of liver cancer. Recently a lipiodol solution of 188Re-labelled diaminedithiol (DD) has been reported to show a high uptake in the liver cancer. We synthesized long-chain alkyl DD derivatives to improve their uptake and retention in tissue. As the length of the alkyl chain increased, tissue uptake and retention also increased due to hydrophobic interaction with lipiodol. Among the synthesized compounds, the lipiodol solution of 188Re-HDD, the DD derivative with the longest side chain (C16), is a promising agent for therapy of liver cancer.
AuthorsY-S Lee, J M Jeong, Y J Kim, J W Chung, J H Park, Y-G Suh, D S Lee, J-K Chung, M C Lee
JournalNuclear medicine communications (Nucl Med Commun) Vol. 23 Issue 3 Pg. 237-42 (Mar 2002) ISSN: 0143-3636 [Print] England
PMID11891481 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Organometallic Compounds
  • Radiopharmaceuticals
  • rhenium diaminedithiol
  • Iodized Oil
Topics
  • Animals
  • Humans
  • Iodized Oil (pharmacokinetics)
  • Liver Neoplasms (metabolism, radiotherapy)
  • Lung (metabolism)
  • Mice
  • Mice, Inbred ICR
  • Organometallic Compounds (chemical synthesis, pharmacokinetics, therapeutic use)
  • Radiopharmaceuticals (chemical synthesis, pharmacokinetics, therapeutic use)
  • Tissue Distribution

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