[A case of successful thrombolysis by recombinant tissue plasminogen activator for postoperative pulmonary thromboembolism].

Abstract

A 52-year-old female suspected of hypercoagulability underwent modified radical hysterectomy and left oophorectomy for uterus cancer and left giant ovarian tumor under general combined with epidural anesthesia. On the day after the operation, the patient complained of dyspnea and developed tachypnea, a low Spo2, and hypotension after the intermittent external pneumatic compression of the legs. Echocardiography showed acute right cardiac failure and pulmonary angiography revealed massive pulmonary thromboembolism. The patient fell into shock with severe hypotension and unconsciousness during the catheter fragmentation and aspiration therapy for pulmonary thrombi. Bolus intravenous injection of monteplase 1.6 million units, a mutant of tissue plasminogen activator with a longer half-life, rapidly improved the shock status and stabilized the hemodynamic condition. Monteplase would be useful for life-threatening pulmonary thromboembolism although the risk of hemorrhagic complication remains.

• Authors: Chiyo Inoue, Toshiyuki Yano, Hironori Tashiro, Hidenori Terasaki
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 51 Issue 2 Pg. 199-202 (Feb 2002) ISSN: 0021-4892 [Print] Japan
• PMID: 11889794 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Recombinant Proteins
• Tissue Plasminogen Activator

Topics

• Anesthesia, Epidural
• Anesthesia, General
• Female
• Humans
• Hysterectomy
• Middle Aged
• Ovariectomy
• Postoperative Complications (drug therapy)
• Pulmonary Embolism (drug therapy)
• Recombinant Proteins (therapeutic use)
• Thrombolytic Therapy
• Tissue Plasminogen Activator (therapeutic use)
• Treatment Outcome