Epstein-Barr virus-negative precursor B cell lymphoblastic lymphoma after liver transplantation: a unique form of posttransplant lymphoproliferative disease.

Abstract

BACKGROUND:

We report a liver transplant patient with Epstein-Barr virus-negative, precursor B cell lymphoblastic lymphoma diagnosed 6 months after transplantation.

PATIENT:

The patient was a 13-year-old boy with acute, fulminant hepatic failure of unknown etiology who underwent cadaveric liver transplantation.

RESULTS:

Six months after the transplant, the patient developed non-tender cervical lymphadenopathy 2 days after a reduction in prednisone dosage. The adenopathy worsened despite withdrawal of immunosuppression, and a biopsy showed precursor B cell lymphoblastic lymphoma. All investigations for Epstein-Barr virus were negative. The patient responded well to chemotherapy and is currently in complete remission 24 months after diagnosis.

CONCLUSIONS:

Precursor B cell lymphoblastic lymphoma has not been previously reported as a form of posttransplant lymphoproliferative disease. We discuss this unique form of posttransplant lymphoproliferative disease and briefly review the clinical and pathological spectrum of posttransplant lymphoproliferative disease.

• Authors: Elizabeth Borges, Judith A Ferry, Alison M Friedmann
• Journal: Transplantation (Transplantation) Vol. 73 Issue 4 Pg. 541-3 (Feb 27 2002) ISSN: 0041-1337 [Print] United States
• PMID: 11889425 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Adolescent
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Cyclophosphamide (administration & dosage)
• Disease Progression
• Doxorubicin (administration & dosage)
• Herpesvirus 4, Human (isolation & purification)
• Humans
• Liver Transplantation (pathology)
• Lymphoma, B-Cell (drug therapy, pathology)
• Lymphoproliferative Disorders (pathology)
• Male
• Postoperative Complications (pathology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, pathology)
• Prednisone (administration & dosage)
• Treatment Outcome
• Vincristine (administration & dosage)