Elevated levels of plasma prekallikrein, high molecular weight kininogen and factor XI in coronary heart disease.
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| Abstract |
Increased levels of hemostatic factors may play a role in the pathogenesis of myocardial infarction by triggering thrombin formation. We measured factor XII (FXII), factor XI (FXI), plasma prekallikrein (PK) and high-molecular-weight kininogen (HK) in 200 patients having survived myocardial infarction for at least 2 months, and in 100 healthy controls. We found significantly elevated levels of FXI clotting activity (FXI:C), HK:C and of the amidolytic activity of PK (PK:Am) among the patients as compared to the controls. Plasma levels of FXI:C, HK:C and PK:Am in the highest quartile were associated with an odds ratio of 1.9 (95% CI: 1.0-3.8), 2.0 (95% CI: 1.0-4.0) and 5.4 (95% CI: 2.6-11.2), respectively, compared to the respective plasma levels in the lowest quartile. After correction for established clinical and laboratory risk factors, the association between PK:Am plasma levels and myocardial infarction remained significant (P=0.0007). Combination of high PK:Am plasma levels and smoking or arterial hypertension, respectively, resulted in a more than additive relative risk for myocardial infarction.
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| Authors | Christoph Merlo, Walter A Wuillemin, Maurice Redondo, Miha Furlan, Irmela Sulzer, Johanna Kremer-Hovinga, Bernd R Binder, Bernhard Lämmle |
| Journal | Atherosclerosis (Atherosclerosis) Vol. 161 Issue 2 Pg. 261-7 (Apr 2002) ISSN: 0021-9150 [Print] Ireland |
| PMID | 11888508 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
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