[Oxidative stress in pregnancies complicated by gestational hypertension (GH), effect of oxidized serum lipoproteins (O-LDL)--the role of antio-LDL antibodies].

Abstract

OBJECTIVE:

To explain correlations between metabolism of serous oxidized lipoproteins, their influence on placental function in pregnancies complicated by GH and intrauterine asphyxia.

MATERIALS AND METHODS:

The group of 233 pregnant women characterised by gestational age between 32-40 weeks were divided into two sub-groups: the study group of 105 women with GH and the control group of 128 healthy pregnant women. In all the subjects doppler flows in umbilical and middle brain artery as well as the serum levels of anti o-LDL antibodies (oLAB) were measured.

RESULTS:

In the study group mean PI values in middle brain artery equal 1.62 +/- 0.41 while in the control group 0.91 +/- 0.16 (p < 0.01), with oLAB values 1133 +/- 24 for the study group and 619 +/- 15 for the controls. Having analysed vascular flows in umbilical artery, mean PI values of 1.41 +/- 0.36 for the study group and 0.63 +/- 0.12 for the control group were obtained, (p < 0.01). The levels of oLAB in these groups were as follows: 1019 +/- 18 for the study group and 600 +/- 12 for the controls.

CONCLUSIONS:

1. In pregnancies complicated by GH an intensified oxidative stress was observed as determined by increased levels of anti o-LDL antibodies (oLAB). 2. Pulsatility indices in umbilical and middle brain artery exhibited enhanced values in pregnancies complicated by GH.

• Authors: P Pawłowicz, G Stachowiak, P Hincz, E Głowacka, M Krekora, H Tchórzewski, J Wilczyński
• Journal: Ginekologia polska (Ginekol Pol) Vol. 72 Issue 12 Pg. 1210-6 (Dec 2001) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Nasilenie stresu oksydacyjnego w ciazach powikłanych nadciśnieniem ciazowym. Efekt działania utlenowanych lipoprotein osocza (O-LDL)--rola przeciwciał anty O-LDL.
• PMID: 11883238 (Publication Type: English Abstract, Journal Article)

Chemical References

• Lipoproteins, LDL
• oxidized low density lipoprotein

Topics

• Adult
• Asphyxia (metabolism, physiopathology)
• Case-Control Studies
• Female
• Gestational Age
• Humans
• Hypertension (blood, metabolism)
• Lipid Peroxidation
• Lipoproteins, LDL (metabolism)
• Oxidative Stress
• Placenta (metabolism, physiopathology)
• Pregnancy
• Pregnancy Complications, Cardiovascular (blood, metabolism)
• Uterus (blood supply)