Abstract | OBJECTIVE: DESIGN: All patients with traumatic-onset spinal cord injury treated with gabapentin were identified and followed up using a longitudinal observational design with two contact points (6 and 36 months after the trial) using a semi-structured interview. The first follow-up interview attempted to capture all 31 patients placed on therapeutic trial. The second follow-up interview attempted to capture those reporting a favorable response (n = 14) to the therapeutic trial at the first follow-up. RESULTS: Of the 27 patients contacted at the first follow-up (87% response rate), 6 (22%) discontinued the trial secondary to intolerable side effects; therefore, the pain analgesic effects of gabapentin in these patients could not be determined. Of the remaining 21 patients, 14 (67%) reported a favorable response (i.e., a 2 or greater point reduction on a 0-10 pain-rating scale). The second follow-up interview captured 11 (79% response rate) of the 14 patients reporting a favorable response at the first interview, and 91% (10 of 11 patients) continued to report that gabapentin was an effective analgesic. There was no evidence to suggest dosing difficulties due to tolerance over the 3-year period. Sedation, dizziness, and forgetfulness were the most common side effects. CONCLUSIONS:
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Authors | John David Putzke, J Scott Richards, Laura Kezar, B L Hicken, T J Ness |
Journal | The Clinical journal of pain
(Clin J Pain)
2002 Mar-Apr
Vol. 18
Issue 2
Pg. 116-21
ISSN: 0749-8047 [Print] United States |
PMID | 11882775
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Acetates
- Amines
- Analgesics
- Cyclohexanecarboxylic Acids
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Acetates
(administration & dosage)
- Amines
- Analgesics
(administration & dosage)
- Chronic Disease
- Cyclohexanecarboxylic Acids
- Female
- Follow-Up Studies
- Gabapentin
- Humans
- Interviews as Topic
(methods)
- Longitudinal Studies
- Male
- Pain
(drug therapy, etiology)
- Pain Measurement
(methods)
- Paraplegia
(complications)
- Spinal Cord Injuries
(complications)
- gamma-Aminobutyric Acid
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