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Neurobehavioural study of subchronic administration of oxydemeton-methyl (insecticide and acaricide) in rats.

Abstract
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium induced hypnosis in rats after intermittent aerosol spray inhalational exposure, for 1/2 hour daily for 7 consecutive days, compared to the saline control group. Further, ED50 +/- SEM value for haloperidol induced catalepsy, CD50 +/- SEM value for pentylenetetrazole induced seizure and CI50 +/- SEM value for electroshock (i.e. the dose of haloperidol, PTZ and intensity of electroshock producing catalepsy or positive seizure response in 50% of rats) were significantly decreased after 7 days exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect, extrapyramidal effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
AuthorsD K Kansal, A Chakrabarti
JournalIndian journal of physiology and pharmacology (Indian J Physiol Pharmacol) Vol. 45 Issue 3 Pg. 329-36 (Jul 2001) ISSN: 0019-5499 [Print] India
PMID11881572 (Publication Type: Journal Article)
Chemical References
  • Antipsychotic Agents
  • Convulsants
  • Hypnotics and Sedatives
  • Insecticides
  • Organothiophosphorus Compounds
  • Barbital
  • methyl demeton
  • Haloperidol
  • Pentylenetetrazole
Topics
  • Animals
  • Antipsychotic Agents (toxicity)
  • Barbital (pharmacology)
  • Behavior, Animal (drug effects)
  • Catalepsy (chemically induced)
  • Convulsants
  • Electroshock
  • Exploratory Behavior (drug effects)
  • Female
  • Haloperidol (toxicity)
  • Hypnotics and Sedatives (pharmacology)
  • Insecticides (toxicity)
  • Male
  • Nervous System (drug effects)
  • Organothiophosphorus Compounds (toxicity)
  • Pentylenetetrazole
  • Rats
  • Rats, Sprague-Dawley
  • Seizures (chemically induced)
  • Sleep (drug effects)
  • Time Factors

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