Abstract |
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium induced hypnosis in rats after intermittent aerosol spray inhalational exposure, for 1/2 hour daily for 7 consecutive days, compared to the saline control group. Further, ED50 +/- SEM value for haloperidol induced catalepsy, CD50 +/- SEM value for pentylenetetrazole induced seizure and CI50 +/- SEM value for electroshock (i.e. the dose of haloperidol, PTZ and intensity of electroshock producing catalepsy or positive seizure response in 50% of rats) were significantly decreased after 7 days exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect, extrapyramidal effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
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Authors | D K Kansal, A Chakrabarti |
Journal | Indian journal of physiology and pharmacology
(Indian J Physiol Pharmacol)
Vol. 45
Issue 3
Pg. 329-36
(Jul 2001)
ISSN: 0019-5499 [Print] India |
PMID | 11881572
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Convulsants
- Hypnotics and Sedatives
- Insecticides
- Organothiophosphorus Compounds
- Barbital
- methyl demeton
- Haloperidol
- Pentylenetetrazole
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Topics |
- Animals
- Antipsychotic Agents
(toxicity)
- Barbital
(pharmacology)
- Behavior, Animal
(drug effects)
- Catalepsy
(chemically induced)
- Convulsants
- Electroshock
- Exploratory Behavior
(drug effects)
- Female
- Haloperidol
(toxicity)
- Hypnotics and Sedatives
(pharmacology)
- Insecticides
(toxicity)
- Male
- Nervous System
(drug effects)
- Organothiophosphorus Compounds
(toxicity)
- Pentylenetetrazole
- Rats
- Rats, Sprague-Dawley
- Seizures
(chemically induced)
- Sleep
(drug effects)
- Time Factors
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