[Five-year experience in treating patients with prostatic hyperplasia patients with permixone (Serenoa repens "Pierre Fabre Medicament)].

Abstract

Specialists of the urologic clinic of the I.M. Sechenov Moscow Medical Academy studied effectiveness of lipidosterol extract Serenoa repens (permixon) in 26 patients with prostatic hyperplasia (total prostate-specific antigen was under 4 ng/ml). The trial has been performed from November 1995 up to now. The drug was taken before meal with a small quantity of water in a total daily dose 320 mg twice a day. Initial IPSS values ranged from 8 to 18 scores (mean 11.65 +/- 0.59). Life quality index was 1 to 4 scores (mean 2.46 +/- 0.15). Initial size of the prostate varied from 26 to 63 cm3 (mean 36.23 +/- 1.57 cm3). Maximal urinary flow rate (Qmax) made up 8.7 to 14.6 ml/s (mean 11.83 +/- 0.31 ml/s). Residual urine was initially 0-60 ml (mean 10.58 +/- 2.91 ml). Permixon significantly reduced the disease symptoms and improved quality of life. 5 years of treatment decreased mean IPSS by 8.8 +/- 0.18 (75.5%). QOL--by 1.31 +/- 0.08 (53.3%), size of the prostate--by 10.81 +/- 0.55 cm3 (29.8%). Neither the symptoms nor quality of life became worse for these five years. The size of the prostate reduced in 16, unchanged in 9 and increased only in 1 patient. Qmax was initially under 15 ml/s and rose after the treatment by 4.13 +/- 0.51 ml/s (35%), on the average. Qmax rose above 15 ml/s in 16 patients. Residual urine increased during the treatment in one patient only. Permixon intolerance was not observed. Thus, continuous 5-year therapy with lipidosterol extract Serenoa repens (permixon) proved highly effective and safe in 26 patients with initial or moderate symptoms of prostatic hyperplasia.

• Authors: Iu G Aliaev, A Z Vinarov, K L Lokshin, L G Spivak
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2002 Jan-Feb Issue 1 Pg. 23-5 ISSN: 1728-2985 [Print] Russia (Federation)
• Vernacular Title: Piatiletniĭ opyt lecheniia permiksonom (Seronoa repens "Pierre Fabre Medicament") bol'nykh s giperplazieĭ predstatel'noĭ zhelezy.
• PMID: 11877967 (Publication Type: Journal Article)

Chemical References

• Androgen Antagonists
• Plant Extracts
• saw palmetto extract

Topics

• Androgen Antagonists (therapeutic use)
• Humans
• Male
• Plant Extracts (therapeutic use)
• Prostatic Hyperplasia (drug therapy, physiopathology)
• Quality of Life
• Serenoa