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[GATA-2 gene expression in leukemia patients and its significance].

AbstractOBJECTIVE:
To investigate GATA-2 gene expression in leukemia patients and its clinical significance.
METHODS:
GATA-2 gene transcripts were detected by reverse transcriptase polymerase chain reaction (RT-PCR), and bcr/abl or PML/RAR alpha transcripts were detected in patients with chronic myeloid leukemia (CML) and acute promyelocytic leukemia (APL), respectively.
RESULTS:
The GATA-2 transcripts were revealed in 93% of acute myeloid leukemia (AML), in 70% of acute lymphoblastic leukemia (ALL), and 83% of CML patients, but not in normal bone marrow and peripheral blood cells. GATA-2 expression in remission patients was similar to newly diagnosed or relapsed patients. In post-transplantation patients, GATA-2 expression was significantly decreased. In these cases GATA-2 transcripts could be detected with bcr/abl fusion gene disappeared in 2 of 12 CML, whereas neither GATA-2 nor PML/RARalpha transcripts could be detected in APL.
CONCLUSION:
GATA-2 transcripts was highly expressed in leukemia patients and had no change in remission but significantly decreased in post-transplantation patients. Detection of GATA-2 expression would give information about the residual leukemia stem cells.
AuthorsL Wang, L Dong, G Liu, Y Lin, J Zhang, S Jia, S Lu, H Pian, B Yao, H Chen
JournalZhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 22 Issue 1 Pg. 27-9 (Jan 2001) ISSN: 0253-2727 [Print] China
PMID11877047 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • GATA2 Transcription Factor
Topics
  • Bone Marrow Cells (metabolism)
  • Cells, Cultured
  • GATA2 Transcription Factor (genetics, metabolism)
  • Gene Expression Regulation, Leukemic
  • Humans
  • Leukemia (genetics, metabolism, pathology)
  • Recurrence

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