Abstract | OBJECTIVE: To investigate GATA-2 gene expression in leukemia patients and its clinical significance. METHODS: RESULTS: The GATA-2 transcripts were revealed in 93% of acute myeloid leukemia (AML), in 70% of acute lymphoblastic leukemia (ALL), and 83% of CML patients, but not in normal bone marrow and peripheral blood cells. GATA-2 expression in remission patients was similar to newly diagnosed or relapsed patients. In post- transplantation patients, GATA-2 expression was significantly decreased. In these cases GATA-2 transcripts could be detected with bcr/abl fusion gene disappeared in 2 of 12 CML, whereas neither GATA-2 nor PML/RARalpha transcripts could be detected in APL. CONCLUSION: GATA-2 transcripts was highly expressed in leukemia patients and had no change in remission but significantly decreased in post- transplantation patients. Detection of GATA-2 expression would give information about the residual leukemia stem cells.
|
Authors | L Wang, L Dong, G Liu, Y Lin, J Zhang, S Jia, S Lu, H Pian, B Yao, H Chen |
Journal | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
(Zhonghua Xue Ye Xue Za Zhi)
Vol. 22
Issue 1
Pg. 27-9
(Jan 2001)
ISSN: 0253-2727 [Print] China |
PMID | 11877047
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- GATA2 Transcription Factor
|
Topics |
- Bone Marrow Cells
(metabolism)
- Cells, Cultured
- GATA2 Transcription Factor
(genetics, metabolism)
- Gene Expression Regulation, Leukemic
- Humans
- Leukemia
(genetics, metabolism, pathology)
- Recurrence
|