Abstract | OBJECTIVE: The activity of lysosomal enzymes is increased in the cerebrospinal fluid of bacterial meningitis, suggesting that inflammation may cause leakage of lysosomal enzymes into the extracellular fluid. Our objective was to study the activity of 3 lysosomal enzymes in cell-free peritoneal fluid of patients with peritoneal inflammation. METHODS: RESULTS: The median beta-galactosidase activity in the culture-positive bacterial peritonitis, mesenteric lymphadenitis, and controls was 175 (range: 63--2210), 50 (range: 37--56), and 16 (range: 8--32), respectively. The beta-glucuronidase was 488 (range: 79--998), 53 (range: 27--98), and 15 (range: 3--22), respectively. The alpha-mannosidase was 801 (range: 100-3172), 78 (range: 33--157), and 41 (range: 16--63), respectively. The differences of the enzyme activities among the groups of the subjects studied were significant, with the exception of the alpha-mannosidase activity between mesenteric lymphadenitis and controls. There was no significant correlation between the enzyme activities and the cytologic or chemical parameters studied. CONCLUSIONS:
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Authors | Nicholas G Beratis, George Georgiou, Maria Eliopoulou |
Journal | Pediatrics
(Pediatrics)
Vol. 109
Issue 3
Pg. E44
(Mar 2002)
ISSN: 1098-4275 [Electronic] United States |
PMID | 11875172
(Publication Type: Evaluation Study, Journal Article)
|
Chemical References |
- Mannosidases
- beta-Galactosidase
- alpha-Mannosidase
- Glucuronidase
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Topics |
- Adolescent
- Appendix
(pathology)
- Ascitic Fluid
(chemistry, cytology, enzymology)
- Bacterial Infections
(diagnosis, enzymology)
- Case-Control Studies
- Child
- Child, Preschool
- Glucuronidase
(metabolism)
- Humans
- Mannosidases
(metabolism)
- Mesenteric Lymphadenitis
(enzymology)
- Peritonitis
(diagnosis, enzymology)
- Predictive Value of Tests
- alpha-Mannosidase
- beta-Galactosidase
(metabolism)
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