The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration.

Abstract

The pharmacokinetics of etamiphylline were determined after an intramuscular (i.m.) dose of 3.5 mg/kg body weight in six healthy camels. Furthermore, the metabolites and drug detection time were evaluated. The data obtained median and (range) were as follows: the terminal elimination half-life (t(1/2 beta), h) was 3.04 (2.03-3.62); apparent total body clearance (Cl/F, L/h/kg) was 1.27 (0.74-2.99); the apparent volume of distribution at steady state (V(ss)/F, L/kg) was 4.94 (3.57-12.54); and renal clearance (Cl(r), L/h/kg) determined in two camels was 0.005 and 0.004, respectively. The detection time of etamiphylline in urine after an i.m. dose of 3.5 mg/kg body weight ranged between 12 and 13 days. Three etamiphylline metabolites were tentatively identified in camels urine: The first one desethyletamiphylline was the main metabolite and resulted from N-deethylation of etamiphylline had a molecular weight of 251, and was detected in urine for about 13-14 days. Theophylline (molecular weight 180) was the second metabolite and resulted from ring N-dealkylation of etamiphylline. It was present in small amounts and was detected for about 5 h after drug administration in urine. The third metabolite, possibly resulted from demethylation of etamiphylline, had a molecular weight of m/z 265, and was present in small amounts and was detected in urine for about 5 h after drug administration.

• Authors: M Elghazali, I A Wasfi, N A Al Katheeri, A A A Hadi, M M Hussein
• Journal: Journal of veterinary pharmacology and therapeutics (J Vet Pharmacol Ther) Vol. 25 Issue 1 Pg. 43-8 (Feb 2002) ISSN: 0140-7783 [Print] England
• PMID: 11874526 (Publication Type: Journal Article)

Chemical References

• Bronchodilator Agents
• etamiphylline
• Theophylline

Topics

• Animals
• Area Under Curve
• Bronchodilator Agents (administration & dosage, blood, pharmacokinetics, urine)
• Camelus (metabolism)
• Female
• Gas Chromatography-Mass Spectrometry (veterinary)
• Injections, Intramuscular (veterinary)
• Kidney (metabolism)
• Male
• Theophylline (administration & dosage, analogs & derivatives, blood, pharmacokinetics, urine)