HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The vitamin B12-deficient rat as a possible model of ketotic hyperglycinemia.

Abstract
The rate of oxidation to respiratory CO2 of both carbon 1 of propionate and carbon 1 of glycine was decreased significantly in vitamin B12-deficient rats, to 50% and 82% of the control rate, respectively. The activity of the glycine synthase system was reduced during vitamin B12 deficiency to 25% of control activity. Serine hydroxymethyltransferase activity was similar for vitamin B12-deficient and control rats. Plasma glycine concentration in vitamin B12-deficient rats (253 +/- 16 nmol/ml) did not differ significantly from that of control rats (226 +/- 12 nmol/ml). Propionate oxidation was significantly impaired in biotin-deficient rats. However, this impairment, to 66% of the control rate, was not as large as that generated by vitamin B12 deficiency. In contrast to the result obtained in vitamin B12-deficient animals, no significant decrease in glycine oxidation could be demonstrated in biotin-deficient animals. Plasma glycine concentration of fasted biotin-deficient rats (339 +/- 26 nmol/ml) did not differ significantly from that of their controls (371 +/- 32 nmol/ml).
AuthorsB O Rowley, V Brothers, T Gerritsen
JournalPediatric research (Pediatr Res) Vol. 9 Issue 10 Pg. 782-6 (Oct 1975) ISSN: 0031-3998 [Print] United States
PMID1187241 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Propionates
  • Carbon Dioxide
  • Biotin
  • Transferases
  • Glycine Hydroxymethyltransferase
  • Carboxy-Lyases
  • Glycine
Topics
  • Acidosis (metabolism)
  • Animals
  • Biotin (deficiency)
  • Carbon Dioxide (metabolism)
  • Carboxy-Lyases (metabolism)
  • Glycine (blood)
  • Glycine Hydroxymethyltransferase (metabolism)
  • Ketosis (metabolism)
  • Liver (enzymology)
  • Male
  • Propionates (metabolism)
  • Rats
  • Transferases (metabolism)
  • Vitamin B 12 Deficiency (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: