Abstract | BACKGROUND: METHODS: The records of 55 patients treated with HPN for >6 months between January 1, 1994 and December 31, 1999 were examined. RESULTS: Thirty patients (55%) had evidence of iron-deficiency anemia. Ten patients were diagnosed at the initiation of HPN, and in 20 patients, iron deficiency developed after receiving HPN. The time between initiation of HPN and development of anemia ranged from 2 to 97 months (mean 28.8+/-26.2 months). Mild iron loss from the gastrointestinal tract seemed to be the predominant reason for iron deficiency. Regular treatment with small amounts of iron in HPN appeared to be safe and efficacious, with no reported side effects. Total dose infusion of iron was associated with adverse reactions in as many as 25% of these patients, although all reactions were mild and self-limited. CONCLUSIONS:
Iron-deficiency anemia is common in patients receiving chronic HPN. Regular small doses of iron in HPN formula, rather than total dose infusion, is the preferred treatment.
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Authors | Lalita Khaodhiar, Mary Keane-Ellison, Nicholas E Tawa, Ann Thibault, Peter A Burke, Bruce R Bistrian |
Journal | JPEN. Journal of parenteral and enteral nutrition
(JPEN J Parenter Enteral Nutr)
2002 Mar-Apr
Vol. 26
Issue 2
Pg. 114-9
ISSN: 0148-6071 [Print] United States |
PMID | 11871735
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anemia, Iron-Deficiency
(drug therapy, epidemiology, etiology)
- Female
- Gastrointestinal Diseases
(complications)
- Gastrointestinal Hemorrhage
(complications)
- Humans
- Infusions, Intravenous
- Iron
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Parenteral Nutrition, Home Total
- Short Bowel Syndrome
(complications, therapy)
- Time Factors
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