Assessment of a potential tumor-seeking manganese metalloporphyrin contrast agent in a mouse model.
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| Abstract |
The performance of a newly developed potential tumor-seeking magnetic resonance (MR) contrast agent alpha-Aqua-13,17-bis(1-carboxypropionyl) carbamoylethyl-3,8-bis(1-phenethyloxyethyl)-beta-hydroxy-2,7,12,18-tetramethyl-porphyrinato manganese (III) (HOP-8P) was tested using a mouse model. Tumor-bearing (SCC-VII) mice were imaged using a 1.5T MR imager before and after intravenous administration of 0.1 mmol/kg of HOP-8P. A biodistribution analysis was performed using an optical emission spectrometer. Significant enhancement of the transplanted tumor was observed in MR images 24 h after intravenous injection of HOP-8P. The biodistribution assessment of manganese also correlated with the results of the imaging study. During the 24-h period following contrast administration, HOP-8P was consistently cleared from the circulation, liver, kidneys, and muscle; however, it was progressively accumulated within the tumor. HOP-8P is a promising tumor-seeking metalloporphyrin MR contrast agent with a wide imaging window.
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| Authors | Yasuo Takehara, Harumi Sakahara, Hatsuko Masunaga, Satoshi Isogai, Nami Kodaira, Masahiro Sugiyama, Hiroyasu Takeda, Tsuneo Saga, Susumu Nakajima, Isao Sakata |
| Journal | Magnetic resonance in medicine (Magn Reson Med) Vol. 47 Issue 3 Pg. 549-53 (Mar 2002) ISSN: 0740-3194 [Print] United States |
| PMID | 11870842 (Publication Type: Journal Article) |
| Copyright | Copyright 2002 Wiley-Liss, Inc. |
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