| Abstract | We measured cerebrospinal fluid (CSF) hypocretin-1 levels in 11 patients with narcolepsy-cataplexy, five with narcolepsy without cataplexy and 12 with idiopathic hypersomnia (IHS). All patients were Japanese. As reported in Caucasian patients, undetectable or very low hypocretin-1 levels were observed in most (9 out of 11) Japanese narcolepsy--cataplexy patients. Our hypocretin-deficient narcoleptics included three prepubertal cases within few months after the disease onset. All nine hypocretin-deficient patients were human leuckocyte antigen (HLA) DR2 positive, while two who had normal CSF hypocretin-1 levels were HLA DR2 negative. In contrast, none of the narcolepsy without cataplexy and IHS subjects had undetectable low levels. Low CSF hypocretin-1 is therefore very specific for HLA DR2 positive narcolepsy-cataplexy, and the deficiency is likely to be established at the early stage of the disease. |
| Authors | Takashi Kanbayashi, Yuichi Inoue, Shigeru Chiba, Rika Aizawa, Yasushi Saito, Haruko Tsukamoto, Yukiharu Fujii, Seiji Nishino, Tetsuo Shimizu
(Affiliation: Department of Neuropsychiatry, Akita University School of Medicine, Hondo, Akita, Japan.takashik at psy.med.akita-u.ac.jp)
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| Journal | Journal of sleep research
(J Sleep Res)
Vol. 11
Issue 1
Pg. 91-3
(Mar 2002)
ISSN: 0962-1105 England |
| PMID | 11869432
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Carrier Proteins
- Intracellular Signaling Peptides and Proteins
- Neuropeptides
- orexins
|
| Topics |
- Adult
- Aged
- Carrier Proteins
(cerebrospinal fluid)
- Child
- Female
- Humans
- Hypersomnolence, Idiopathic
(cerebrospinal fluid)
- Intracellular Signaling Peptides and Proteins
- Male
- Middle Aged
- Narcolepsy
(cerebrospinal fluid)
- Neuropeptides
(cerebrospinal fluid)
|
