Abstract | BACKGROUND: Kidneys are involved in tryptophan (TRP) metabolism in two ways. They eliminate TRP derivatives on the one hand, and they produce several enzymes taking part in TRP metabolism mainly via the kynurenine pathway on the other. The aim of the present study was to examine the time-course of changes in the peripheral kynurenine products degradation during experimental chronic renal failure in rats. METHODS: RESULTS: A decreased TRP level and significant increase in kynurenine pathway metabolite concentrations in plasma of uremic rats were found. CONCLUSIONS: Substantial disturbances in the peripheral kynurenic pathway were observed in experimental chronic renal failure. They may contribute to several symptoms of uremia.
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Authors | D Pawlak, A Tankiewicz, P Mysliwiec, W Buczko |
Journal | Nephron
(Nephron)
Vol. 90
Issue 3
Pg. 328-35
(Mar 2002)
ISSN: 1660-8151 [Print] Switzerland |
PMID | 11867954
(Publication Type: Journal Article)
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Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Xanthurenates
- ortho-Aminobenzoates
- anthranilic acid
- Kynurenine
- xanthurenic acid
- Tryptophan
- Urea
- Creatinine
- Quinolinic Acid
- Kynurenic Acid
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Topics |
- Animals
- Chromatography, High Pressure Liquid
- Creatinine
(blood)
- Kidney
(metabolism, surgery)
- Kidney Failure, Chronic
(blood, metabolism)
- Kynurenic Acid
(blood)
- Kynurenine
(blood)
- Male
- Quinolinic Acid
(blood)
- Rats
- Rats, Wistar
- Time Factors
- Tryptophan
(metabolism)
- Urea
(blood)
- Xanthurenates
(blood)
- ortho-Aminobenzoates
(blood)
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