Abstract | OBJECTIVE: METHODS: 9 cases of EHE were examined by light microscopy and immunohistochemistry, 1 case with ultrastructural observation. RESULTS: The patients' age ranged from 16 to 47 years (mean 32 years). The lesions occurred in both sexes and presented at a variety of sites including head and facial area (4 cases), upper limbs (3 cases) and lower limbs (2 cases). The morphological characters were: (1) "epithelioid" or "histiocytoid" tumor cells; (2) rounded or polygonal tumor cells arranged in nests, cords and irregular patterns; (3) the tumor cells were embedded in myxoid or hyaline matrix; (4) primitive lumen formation within a single tumor cell (intracytoplasmic lumens); (5) lack of pleomorphism, mitotic activity and necrosis; (6) presence of spindle cell hemangioendothelioma in some cases; (7) osteoclast like giant cells scattered throughout the entire lesion were observed in one case. Immunohistochemistry studies on 7 cases found that tumor cells were positive for vimentin (7/7), factor VIII-RAg (5/7), CD31 (5/7), CD34 (5/7), cytokeratin (2/7), CD68 and alpha-AT (1/7). Ultrastructural study of 1 case demonstrated Weibel-Palade bodies and an abundance of intermediate filaments in the cytoplasm. The follow-up of 6 cases found that 3 cases developed local recurrences but none of them metastasized. CONCLUSIONS: EHE is a distinctive low-grade sarcoma whose etiology remains unknown. Recognizing its morphological characters is important to avoid confusion with other similar lesions.
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Authors | R Lai, Y Tian, X Feng, Z Wang, W Zhang |
Journal | Zhonghua bing li xue za zhi = Chinese journal of pathology
(Zhonghua Bing Li Xue Za Zhi)
Vol. 30
Issue 3
Pg. 177-9
(Jun 2001)
ISSN: 0529-5807 [Print] China |
PMID | 11866972
(Publication Type: Journal Article)
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Chemical References |
- Platelet Endothelial Cell Adhesion Molecule-1
- Vimentin
- von Willebrand Factor
|
Topics |
- Adolescent
- Adult
- Diagnosis, Differential
- Female
- Follow-Up Studies
- Head and Neck Neoplasms
(chemistry, pathology)
- Hemangioendothelioma, Epithelioid
(chemistry, pathology)
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Platelet Endothelial Cell Adhesion Molecule-1
(analysis)
- Vimentin
(analysis)
- von Willebrand Factor
(analysis)
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