Abstract |
Interferon (IFN)-gamma-mediated immunity plays an important role in host defense against intracellular pathogens, especially mycobacteria. Six Japanese children with bacille Calmette-Guérin (BCG) osteomyelitis were evaluated (1 disseminated, 3 multiple, and 2 solitary types) for mutations of genes involved in interleukin-12-dependent, IFN-gamma-mediated immunity. Heterozygous small deletions with frameshift (818del4 and 811del4) that are consistent with the diagnosis of partial dominant IFN-gamma receptor 1 (IFN-gammaR1) deficiency were detected in 3 unrelated patients. Expression of IFN-gammaR1 on monocytes was significantly increased in all 3 patients. Screening of family members with recurrent and disseminated mycobacterial infections found the identical deletion in 1 of the fathers. Antimycobacterial treatment was effective in these patients and resulted in good clinical outcome. This study demonstrated that partial dominant IFN-gammaR1 deficiency was the most common in Japanese patients who showed predisposition to curable BCG osteomyelitis.
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Authors | Yuka Sasaki, Akihiko Nomura, Koichi Kusuhara, Hidetoshi Takada, Saifuddin Ahmed, Kaoru Obinata, Keisuke Hamada, Yuri Okimoto, Toshiro Hara |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 185
Issue 5
Pg. 706-9
(Mar 01 2002)
ISSN: 0022-1899 [Print] United States |
PMID | 11865431
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- BCG Vaccine
- Receptors, Interferon
- Interleukin-12
- Interferon-gamma
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Topics |
- Adult
- BCG Vaccine
(adverse effects)
- Female
- Gene Deletion
- Humans
- Infant
- Interferon-gamma
(genetics, metabolism)
- Interleukin-12
(genetics, metabolism)
- Japan
- Male
- Mutation
- Mycobacterium Infections
(microbiology)
- Osteomyelitis
(etiology, genetics)
- Receptors, Interferon
(genetics, metabolism)
- Sequence Analysis, DNA
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