The use of naloxone in small doses in complex therapy of postabstinent heroin syndrome: enkephalinase mechanisms.

Abstract

The use of naloxone hydrochloride (0.2-0.4 mg) in complex therapy of adolescent heroin addicts significantly prolonged the half-life of serum leu-enkephalin, slightly elevated the thresholds of thermal nociceptive reactions, and improved some clinical indices (considerably reduced drug addiction, eliminated affective disorders, etc.), which are important for deactualization of drug addiction and promoting remission.

• Authors: S V Litvinova, A V Nadezhdin, V V Shul'govskii, A L Kalyuzhnyi, S N Avdeev, E Y Tetenova, N N Terebilina, L F Panchenko
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 132 Issue 5 Pg. 1070-2 (Nov 2001) ISSN: 0007-4888 [Print] United States
• PMID: 11865324 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Narcotic Antagonists
• Naloxone
• Heroin

Topics

• Adolescent
• Age Factors
• Heroin (adverse effects)
• Humans
• Male
• Naloxone (pharmacology)
• Narcotic Antagonists (pharmacology)
• Substance Withdrawal Syndrome (drug therapy)
• Substance-Related Disorders
• Temperature
• Time Factors