HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Treatment of renal artery fibromuscular dysplasia with balloon angioplasty: a prospective follow-up study.

AbstractOBJECTIVES:
to assess restenosis rates and blood pressure response after percutaneous transluminal renal angioplasty (PTRA) in patients treated for fibromuscular dysplastic renal artery stenosis.
METHODS:
a prospective 12-month follow-up study of 27 patients with 31 treated renal artery stenosis. Follow-up assessment included colour-coded duplex sonography (CCD) of renal arteries, monitoring of blood pressure, antihypertensive medication, and creatinine measurements before discharge and at 3, 6, and 12 months. Primary end point was defined as a haemodynamically significant restenosis >60% assessed by CCD.
RESULTS:
there was a cumulative 23% restenosis rate at 12 months. Arterial hypertension was cured or improved in 93% of patients immediately after the intervention and remained cured/improved in 74% of patients at 12 months of follow-up. Renal failure present in five patients before PTRA stabilised or improved in all patients.
CONCLUSION:
although restenosis rate after PTRA in fibromuscular dysplasia is as high as in non-ostial atherosclerotic lesions, there remains a considerable higher therapeutic effect. Profound pressure response and recurrent arterial hypertension with restenosis support the high probability of a renovascular origin of arterial hypertension in this young and otherwise healthy population compared to patients with atherosclerotic renal artery lesions.
AuthorsM Birrer, D D Do, F Mahler, J Triller, I Baumgartner
JournalEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (Eur J Vasc Endovasc Surg) Vol. 23 Issue 2 Pg. 146-52 (Feb 2002) ISSN: 1078-5884 [Print] England
PMID11863332 (Publication Type: Comparative Study, Journal Article)
CopyrightCopyright 2002 Harcourt Publishers Limited.
Chemical References
  • Creatinine
Topics
  • Adult
  • Aged
  • Angioplasty, Balloon (instrumentation)
  • Blood Pressure (physiology)
  • Blood Vessel Prosthesis
  • Creatinine (blood)
  • Female
  • Fibromuscular Dysplasia (complications, therapy)
  • Follow-Up Studies
  • Graft Occlusion, Vascular (etiology)
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Renal Artery Obstruction (complications, therapy)
  • Stents
  • Time Factors
  • Treatment Outcome
  • Vascular Patency (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: