HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The use of antileukotrienes in paediatrics.

Abstract
Allergic diseases include a variety of different illnesses (rhinitis, conjunctivitis, asthma, urticaria, dermatitis) whose physiological and pathological basis is the release of chemical mediators such as histamine, PAF (platelet activating factor), metabolites of arachidonic acid and chemotactic factors from mastocytes, basophils and eosinophils. The numerous drugs used for allergy treatment now include the new pharmacological category of cysteinyl leukotriene antagonists. The cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are chemical mediators of the inflammation involved in the pathogenesis of asthma, the biological effects of which are bronchial constriction and an increase in both mucus secretion and vascular permeability. Recent studies carried out above all on adult patients suggest that antileukotrienes can play an important part not only in the acute phase but also in controlling the chronic development of bronchial asthma. Antileukotrienes have also been successfully used by some authors to control atopic dermatitis and urticaria. Though further controlled testing will be required, these applications broaden the possible range of treatments for allergic disease in all its many aspects.
AuthorsA Aprile, S Lucarelli, B Vagnucci, T Frediani
JournalEuropean review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) 2001 Mar-Apr Vol. 5 Issue 2 Pg. 53-7 ISSN: 1128-3602 [Print] Italy
PMID11863319 (Publication Type: Journal Article, Review)
Chemical References
  • Leukotriene Antagonists
  • Leukotrienes
Topics
  • Adolescent
  • Asthma (drug therapy)
  • Child
  • Humans
  • Leukotriene Antagonists (therapeutic use)
  • Leukotrienes (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: