| Abstract | BACKGROUND: Topical corticosteroids are useful for the treatment of pediatric dermatoses. However, concerns regarding possible systemic and topical toxicities have limited the use of moderate-potency corticosteroids in children. OBJECTIVE: Our purpose was to characterize the safety of fluticasone propionate cream in children. METHODS: Children between 3 months and 5 years 11 months (n = 32) and 3 up to 6 years of age (n = 19) with moderate to severe atopic dermatitis (> or =35% body surface area; mean body surface area treated, 64%) were treated with fluticasone propionate cream, 0.05% twice daily for 3 to 4 weeks. Serum cortisol response, fluticasone levels, skin changes, and adverse events were analyzed. RESULTS: Mean cortisol levels were similar at baseline (13.76 +/- 6.94 microg/dL prestimulation and 30.53 +/- 7.23 microg/dL poststimulation) and at end of treatment (12.32 +/- 6.92 microg/dL prestimulation and 28.84 +/- 7.16 microg/dL poststimulation). Only 2 of 43 children had end-treatment poststimulation values less than 18.0 microg/dL. No significant adverse cutaneous effects were noted. CONCLUSION: Fluticasone propionate cream 0.05% appears to be safe for the treatment of severe eczema for up to 4 weeks in children 3 months of age and older. |
| Authors | S F Friedlander, A A Hebert, D B Allen, Fluticasone Pediatrics Safety Study Group
(Affiliation: Department of Pediatrics and Medicine (Dermatology), University of California-San Diego School of Medicine and Children's Hospital San Diego, 3030 Children's Way, Suite 408, San Diego, CA 92123, USA.)
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| Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 46
Issue 3
Pg. 387-93
(Mar 2002)
ISSN: 0190-9622 United States |
| PMID | 11862174
(Publication Type: Clinical Trial, Clinical Trial, Phase IV, Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Androstadienes
- Anti-Inflammatory Agents
- Ointments
- Hydrocortisone
- fluticasone
|
| Topics |
- Administration, Topical
- Androstadienes
(administration & dosage, adverse effects, therapeutic use)
- Anti-Inflammatory Agents
(administration & dosage, adverse effects, therapeutic use)
- Case-Control Studies
- Child
- Child, Preschool
- Dermatitis, Atopic
(drug therapy)
- Female
- Humans
- Hydrocortisone
(blood)
- Infant
- Male
- Ointments
- Safety
- Time Factors
|
