Abstract | PURPOSE: METHODS: Nine consecutive eyes of seven patients with GDD were treated with LSCT. Limbal grafts were obtained from cadaver eyes. All eyes underwent lamellar or penetrating keratoplasty simultaneously with LSCT. Intensive epithelial management and immunosuppression therapy was performed. RESULTS: With a mean observation period of 4 years, eight (88.9%) of nine eyes did not show any signs of recurrence. Five grafts remained clear, and seven eyes had an improvement in vision. Glaucoma and rejection were observed in five and three eyes, respectively, and two eyes with glaucoma required surgical intervention. CONCLUSIONS: Limbal stem cell transplantation is effective for the prevention of recurrence in GDD. Control of intraocular pressure and rejection are the keys to long-term maintenance of clear grafts.
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Authors | Jun Shimazaki, Shigeto Shimmura, Kazuo Tsubota |
Journal | Cornea
(Cornea)
Vol. 21
Issue 2
Pg. 177-80
(Mar 2002)
ISSN: 0277-3740 [Print] United States |
PMID | 11862090
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Amyloidosis
(surgery)
- Cell Transplantation
- Child
- Corneal Diseases
(surgery)
- Corneal Stroma
- Corneal Transplantation
- Epithelial Cells
(transplantation)
- Female
- Graft Survival
(drug effects)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Keratoplasty, Penetrating
- Limbus Corneae
(cytology)
- Male
- Middle Aged
- Stem Cell Transplantation
- Treatment Outcome
- Visual Acuity
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