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[Distribution of HIV resistance CCR5-delta 32, CCR2-64 I and SDF1-3'A alleles and their polymorphisms in the Han population in China].

AbstractOBJECTIVE:
To study the frequency and polymorphism of three mutations (CCR5(Delta)32, CCR2-64I and SDF1-3'A alleles) conferring resistance to determined HIV-1/AIDS in the indigenous Han population in China.
METHODS:
The study population included 1,267 subjects, of which consisted 98.7% (1,251/1,267) Han people. The genotypes of the three mutations were respectively, detected by polymerase chain reaction (PCR) for CCR5(Delta)32 mutation, or by PCR/RFLP (restriction fragment length polymorphism) assay with the digestion of restriction endonuclease Bsa BI and Msp I for CCR2-64I and SDF1-3'A mutations. DNA sequencing was employed to confirm the accuracy of PCR or PCR/RFLP products.
RESULTS:
The frequency of the mutant alleles were: 0.00119 for CCR5(Delta)32; 0.20023 for CCR2-64I, and 0.28723 for SDF1-3'A. The three heterozygous CCR5-wt/Delta32 mutants were identified and no homozygotes were detected in indigenous Han population. The frequencies of CCR2-64I and SDF1-3'A alleles in China were higher than those of Caucasians descents in the USA and Europe.
CONCLUSION:
Our data was the first findings on the frequency and polymorphism of CCR5(Delta)32, CCR2-64I and SDF1-3'A alleles in indigenous Han population in China which implied that the indigenous Han people might have a higher genetic susceptibility to the infection of sexually transmitted HIV-1 (R-5) strain. Further study is needed to clarify the significance of higher frequency of CCR2-64I and SDF1-3'A alleles in Han population.
AuthorsF Wang, L Jin, Z Lei, H Shi, W Hong, D Xu, M Shi, J Jiang, Y Wang, B Zhang, M Liu, Y Li
JournalZhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi (Zhonghua Liu Xing Bing Xue Za Zhi) Vol. 21 Issue 4 Pg. 256-60 (Aug 2000) ISSN: 0254-6450 [Print] China
PMID11860793 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CCR2 protein, human
  • CXCL12 protein, human
  • Chemokine CXCL12
  • Chemokines, CXC
  • Receptors, CCR2
  • Receptors, CCR5
  • Receptors, Chemokine
Topics
  • Alleles
  • Chemokine CXCL12
  • Chemokines, CXC (genetics)
  • China (ethnology)
  • Female
  • Genotype
  • HIV Infections (genetics, virology)
  • HIV-1 (genetics)
  • Humans
  • Male
  • Mutation
  • Polymorphism, Genetic
  • Receptors, CCR2
  • Receptors, CCR5 (genetics)
  • Receptors, Chemokine (genetics)

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