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Long-term administration of high-dose deferoxamine 2 days per week in thalassemic patients.

AbstractOBJECTIVE:
Compliance with parenteral administration of deferoxamine is often poor in thalassemic patients with iron overload. We tested the efficacy and tolerance of the drug at high dosage 2 d per week for 24 months in two adult thalassemic patients with permanently high serum ferritin using a portable pump and an implanted chamber.
METHODS:
Deferoxamine was administered using a pressure-operated portable pump through an implanted chamber. The patients were infused over 48 h every week with 198 mg/kg/d (patient 1) and 170 mg/kg/d (patient 2). Serum ferritin levels were measured at regular intervals.
RESULTS:
Serum ferritin decreased progressively from 2967 to 457 microg/L in patient 1 and from 6476 to 1951 microg/L in patient 2. Compliance and tolerance to treatment were excellent in the two patients.
CONCLUSION:
Intravenous administration of high-dose deferoxamine over 48 h per week using a portable pump and implanted chamber improved compliance in two thalassemic adult patients, resulting in a significant decrease in iron overload. We suggest that high-dose chelation therapy should be assessed in selected groups of iron-overload thalassemic patients receiving regular blood transfusions.
AuthorsI Hagège, A Becker, T Kerdaffrec, A Kanfer, R Girot
JournalEuropean journal of haematology (Eur J Haematol) Vol. 67 Issue 4 Pg. 230-1 (Oct 2001) ISSN: 0902-4441 [Print] England
PMID11860443 (Publication Type: Journal Article)
Chemical References
  • Chelating Agents
  • Ferritins
  • Iron
  • Deferoxamine
Topics
  • Adult
  • Chelating Agents (administration & dosage, therapeutic use)
  • Chelation Therapy (methods)
  • Deferoxamine (administration & dosage, therapeutic use)
  • Female
  • Ferritins (analysis)
  • Humans
  • Infusion Pumps
  • Iron
  • Iron Overload (drug therapy, etiology)
  • Male
  • Thalassemia (therapy)
  • Transfusion Reaction
  • Treatment Outcome

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