Abstract | OBJECTIVE: Compliance with parenteral administration of deferoxamine is often poor in thalassemic patients with iron overload. We tested the efficacy and tolerance of the drug at high dosage 2 d per week for 24 months in two adult thalassemic patients with permanently high serum ferritin using a portable pump and an implanted chamber. METHODS:
Deferoxamine was administered using a pressure-operated portable pump through an implanted chamber. The patients were infused over 48 h every week with 198 mg/kg/d (patient 1) and 170 mg/kg/d (patient 2). Serum ferritin levels were measured at regular intervals. RESULTS: Serum ferritin decreased progressively from 2967 to 457 microg/L in patient 1 and from 6476 to 1951 microg/L in patient 2. Compliance and tolerance to treatment were excellent in the two patients. CONCLUSION:
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Authors | I Hagège, A Becker, T Kerdaffrec, A Kanfer, R Girot |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 67
Issue 4
Pg. 230-1
(Oct 2001)
ISSN: 0902-4441 [Print] England |
PMID | 11860443
(Publication Type: Journal Article)
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Chemical References |
- Chelating Agents
- Ferritins
- Iron
- Deferoxamine
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Topics |
- Adult
- Chelating Agents
(administration & dosage, therapeutic use)
- Chelation Therapy
(methods)
- Deferoxamine
(administration & dosage, therapeutic use)
- Female
- Ferritins
(analysis)
- Humans
- Infusion Pumps
- Iron
- Iron Overload
(drug therapy, etiology)
- Male
- Thalassemia
(therapy)
- Transfusion Reaction
- Treatment Outcome
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