Efficacy of a new class of perfluoropolyethers in the prevention of irritant contact dermatitis.

Abstract	Perfluoropolyethers (Fomblin HC products) are chemical non-reactive polymers with special physico-chemical properties that recently showed promise as protective preparations in the prevention of irritant contact dermatitis. We evaluated the efficacy of a new class of perfluoropolyethers (perfluoropolyether phosphate, Fomblin HC/P2) in the prevention of experimentally induced cumulative irritant contact dermatitis if applied prior to irritation. A panel of 20 healthy volunteers was tested with a repetitive irritation test using 4 standard irritants (sodium lauryl sulphate of highest purity, sodium hydroxide, lactic acid and toluene) in a randomized double-blind study. Application sites were assessed clinically and by the use of bioengineering techniques (transepidermal water loss and chromametry). Three gel preparations each containing 5% perfluoropolyether phosphate showed significant efficacy against irritation due to sodium lauryl sulphate and sodium hydroxide, while one test preparation containing 2% showed inferior benefit, indicating a dose-related effect. Preparations containing perfluoropolyether phosphates can be recommended for workplaces with water-soluble irritants. Further studies under real workplace conditions are indicated.
Authors	S Schliemann-Willers, W Wigger-Alberti, P Elsner
Journal	Acta dermato-venereologica (Acta Derm Venereol) 2001 Nov-Dec Vol. 81 Issue 6 Pg. 392-4 ISSN: 0001-5555 [Print] Sweden
PMID	11859938 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References	Fluorocarbons Gels Irritants Ointment Bases Ointments Lactic Acid Sodium Dodecyl Sulfate Toluene Sodium Hydroxide
Topics	Adolescent Adult Dermatitis, Irritant (etiology, pathology, prevention & control) Dermatitis, Occupational (prevention & control) Dose-Response Relationship, Drug Double-Blind Method Erythema (chemically induced, pathology) Female Fluorocarbons (therapeutic use) Gels Humans Irritants Lactic Acid (adverse effects) Male Ointment Bases Ointments Sodium Dodecyl Sulfate (adverse effects) Sodium Hydroxide (adverse effects) Toluene (adverse effects) Water Loss, Insensible

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