Nematocidal activity of isoquinoline alkaloids against a species of diplogastridae.

Abstract

We examined the nematocidal activity of various isoquinoline alkaloids. The method of evaluating nematocidal activity involved the microscopic examination of the state of larvae after the compound was administered to determine the minimum lethal concentration (MLC). In addition, cytotoxic activity (IC50) was examined using HL-60 culture cells. The compound dehydrocorydaline was found to have considerable nematocidal activity and weak cytotoxicity; its cytotoxicity value was equal to that of thiabendazole. We conclude that dehydrocorydaline, with its attractive balance between nematocidal activity and weak cytotoxicity, is the most promising of the tested compounds as a possible remedy for parasitic diseases.

• Authors: Rinako Matsuhashi, Tadaaki Satou, Kazuo Koike, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Tamotsu Nikaido
• Journal: Planta medica (Planta Med) Vol. 68 Issue 2 Pg. 169-71 (Feb 2002) ISSN: 0032-0943 [Print] Germany
• PMID: 11859472 (Publication Type: Letter)

Chemical References

• Alkaloids
• Antinematodal Agents
• Drugs, Chinese Herbal
• Isoquinolines
• dehydrocorydalin
• isoquinoline
• Thiabendazole

Topics

• Alkaloids (isolation & purification, pharmacology)
• Animals
• Antinematodal Agents (pharmacology)
• Drugs, Chinese Herbal
• HL-60 Cells
• Humans
• Inhibitory Concentration 50
• Isoquinolines (isolation & purification, pharmacology)
• Nematoda (drug effects)
• Papaveraceae
• Thiabendazole (pharmacology)