Pharmacological profile of oxaprozin eye drops.

Abstract

The effects of eye drops containing a propionic acid derivative (oxaprozin) at 0.1% concentration on ocular inflammation produced by sodium arachidonate in the rabbit's eye were evaluated. Furthermore, the aqueous bioavailability of the drug formulation in the uninflamed and inflamed eyes was evaluated. Oxaprozin eye drops significantly reduced the signs of ocular inflammation elicited by sodium arachidonate on conjunctiva and iris. Oxaprozin treatment significantly reduced the levels of polymorphonuclear leukocytes and protein concentration in aqueous samples obtained from the eyes treated with arachidonate. Present data suggest, for the first time, that oxaprozin may be employed topically to prevent ocular reactions where the arachidonic acid cascade is activated.

• Authors: Claudio Bucolo, Adriana Maltese
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 18 Issue 1 Pg. 75-81 (Feb 2002) ISSN: 1080-7683 [Print] United States
• PMID: 11858617 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Propionates
• Oxaprozin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Aqueous Humor (metabolism)
• Area Under Curve
• Biological Availability
• Conjunctivitis (drug therapy)
• Male
• Neutrophils (drug effects, physiology)
• Oxaprozin
• Propionates (pharmacokinetics, pharmacology, therapeutic use)
• Rabbits