Abstract |
In most ethnic groups genetic susceptibility to rheumatoid arthritis (RA) is associated with certain HLA-DRB1 alleles encoding a similar sequence motif called the 'shared epitope' (SE) spanning amino acid positions 70 to 74 in the third diversity region of the outermost domain of the HLA-DRB1 molecule. We examined the association of the SE and RA in 83 Colombian women with established RA and 90 healthy controls. The group HLA-DRB1*04 was associated with RA with respect to controls (47% vs 18%, respectively. OR: 4.1, 95%CI: 2.1-8.2, P < 0.001). HLA-DRB1 alleles carrying the SE QRRAA, but not those carrying QKRAA or RRRAA, were associated with disease (OR: 3.7, 95%CI: 1.73-7.83, P = 0.0009). This association was stronger among HLA-DRB1*04 carriers (OR: 23, 95%CI: 1.3-414, P = 0.002). In our population, the SE QRRAA expressed in DRB1*04 alleles appears critical in identifying women with increased susceptibility to RA.
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Authors | J M Anaya, P A Correa, R D Mantilla, M Arcos-Burgos |
Journal | Genes and immunity
(Genes Immun)
Vol. 3
Issue 1
Pg. 56-8
(Feb 2002)
ISSN: 1466-4879 [Print] England |
PMID | 11857065
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-DR Antigens
- HLA-DRB1 Chains
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Topics |
- Adult
- Alleles
- Amino Acid Motifs
- Amino Acid Sequence
- Arthritis, Rheumatoid
(genetics)
- Colombia
- Cross-Sectional Studies
- Female
- Gene Dosage
- Genetic Predisposition to Disease
- HLA-DR Antigens
(chemistry, genetics)
- HLA-DRB1 Chains
- Heterozygote
- Humans
- Middle Aged
- Protein Structure, Tertiary
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