Colorectal cancer risk: the impact of evidence of a field effect of carcinogenesis on blinded diagnosis using an anti-adenoma antibody test performed on colonoscopic effluent.

Abstract

To better define high-risk populations for colorectal cancer screening, we used anti-adenoma antibody Adnab-9, comparing colonic effluent and tissue field effects from 45 high-risk and 11 control patients. We included Adnab-9 binding at the tissue level to elucidate the impact of a field effect of carcinogenesis contributing to the outcome of the effluent binding test. In high-risk patients, 64% of the left-sided effluent samples were positive (P < 0.002); 67% showed a field effect (P < 0.006); 82% of combined tests were positive (P < 0.001), as compared to 9%, 18%, and 27% respectively, of controls. Adnab-9 binding correlates with increased colorectal cancer risk associated with a field effect of carcinogenesis.

• Authors: Martin Tobi, Shivkumar Prabhu, Rhonda E Gage, Tashia Orr, Michael J Lawson
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 47 Issue 2 Pg. 317-21 (Feb 2002) ISSN: 0163-2116 [Print] United States
• PMID: 11855547 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antibodies, Monoclonal

Topics

• Adenoma (immunology)
• Antibodies, Monoclonal (immunology)
• Case-Control Studies
• Colonoscopy
• Colorectal Neoplasms (diagnosis, epidemiology)
• Enzyme-Linked Immunosorbent Assay
• Humans
• Risk Assessment
• Therapeutic Irrigation