Gas chromatographic-mass spectrometric study of volatile organic metabolites in urines of patients with diabetes mellitus.

Abstract

Abnormally increased concentrations of the aliphatic alcohols ethanol, n-propanol, isobutanol, n-butanol and isopentanol and the ketones 4-heptanone and cyclohexanone in human urine reflect metabolic disorders related to diabetes mellitus. For the determination of these low-molecular-weight metabolites, the components are trapped on an absorbent, separated by gas chromatography and identified by mass spectrometry. After standardization of the adsorption and desorption techniques, the procedure is applicable for comparative studies and for screening.

• Authors: H M Liebich, O Al-Babbili
• Journal: Journal of chromatography (J Chromatogr) Vol. 112 Pg. 539-50 (Oct 29 1975) Netherlands
• PMID: 1184687 (Publication Type: Journal Article)

Chemical References

• Alcohols
• Butanols
• Butanones
• Cyclohexanones
• Ketones
• Pentanols
• Pyrroles
• Ethanol
• 1-Propanol

Topics

• 1-Propanol (urine)
• Adsorption
• Adult
• Aged
• Alcohols (urine)
• Butanols (urine)
• Butanones (urine)
• Chromatography, Gas
• Cyclohexanones (urine)
• Diabetes Mellitus (urine)
• Ethanol (urine)
• Female
• Gas Chromatography-Mass Spectrometry
• Humans
• Ketones (urine)
• Male
• Mass Screening
• Mass Spectrometry
• Middle Aged
• Molecular Weight
• Pentanols (urine)
• Pyrroles (urine)