Abstract | BACKGROUND: OBJECTIVES: METHODS: We studied 102 consecutive patients (mean age 65.2 +/- 11 years) with newly diagnosed lung cancer (96 males, 94%, with a mean age of 66.3 +/-10.5 years). All patients had a 5-year follow-up. Measurements of the serum tumor markers were performed on initial diagnosis. RESULTS: Eighty-four patients (82%) had non-small-cell lung cancer (NSCLC) and 18 (18%) small-cell lung cancer (SCLC). From the 84 patients with NSCLC, 34 patients (33%) had squamous-cell lung cancer, 23 (22%) adenocarcinoma and 23 (22%) large-cell carcinomas. The overall median survival was 8.5 months. All SCLC patients had extensive disease with a median survival of 10.1 months and NSCLC patients of 8.4 months. Significant differences in the mean values of NSE and CYFRA 21-1 were observed between SCLC and NSCLC. In NSCLC, CYFRA 21-1, TPA, CA 125 and SCCAg serum levels were related to the stage of the disease at diagnosis, and CYFRA 21-1, NSE, TPA and CA-125 were related to a poor outcome. None of the above tumor markers was related to survival in the SCLC group. CONCLUSION:
CYFRA 21-1 and NSE may help to differentiate cell types in lung cancer patients. Also, CYFRA 21-1 with TPA and CA 125 may provide useful information regarding the staging of the disease at diagnosis and the prognosis of patients with NSCLC.
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Authors | Kostas D Hatzakis, Marios E Froudarakis, Demosthenes Bouros, Nikolaos Tzanakis, Nikolaos Karkavitsas, Nikolaos M Siafakas |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 69
Issue 1
Pg. 25-9
( 2002)
ISSN: 0025-7931 [Print] Switzerland |
PMID | 11844959
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- CA-125 Antigen
- Carcinoembryonic Antigen
- Keratin-19
- antigen CYFRA21.1
- Keratins
- Phosphopyruvate Hydratase
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Topics |
- Adenocarcinoma
(mortality, pathology, therapy)
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Antigens, Neoplasm
(analysis)
- Biomarkers, Tumor
(analysis)
- CA-125 Antigen
(analysis)
- Carcinoembryonic Antigen
(analysis)
- Carcinoma, Large Cell
(mortality, pathology, therapy)
- Carcinoma, Non-Small-Cell Lung
(mortality, pathology, therapy)
- Carcinoma, Squamous Cell
(mortality, pathology, therapy)
- Female
- Humans
- Keratin-19
- Keratins
- Lung Neoplasms
(mortality, pathology, therapy)
- Male
- Middle Aged
- Phosphopyruvate Hydratase
(analysis)
- Probability
- Prognosis
- Prospective Studies
- Regression Analysis
- Sensitivity and Specificity
- Survival Analysis
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