Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery.

Abstract

Seventy-four patients undergoing laparoscopic gynaecological surgery were randomly allocated to two groups receiving cyclizine 50 mg or ondansetron 4 mg at induction of anaesthesia. Anaesthetic and postoperative analgesia regimens were standardised. Approximately half of the patients in each group experienced some degree of postoperative nausea and vomiting (cyclizine, 56%; ondansetron, 54%). There was no difference between groups in respect of pre- and postdischarge incidence. Mean (SD) time to eye opening was significantly prolonged in the cyclizine group [10 (4) min vs. 8 (2) min; p < 0.001], but this had no influence on discharge times. Cyclizine and ondansetron appear equally effective in preventing postoperative nausea and vomiting but the 10-fold price differential favours cyclizine.

• Authors: K Grimsehl, J B Whiteside, N Mackenzie
• Journal: Anaesthesia (Anaesthesia) Vol. 57 Issue 1 Pg. 61-5 (Jan 2002) ISSN: 0003-2409 [Print] England
• PMID: 11843745 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antiemetics
• Histamine H1 Antagonists
• Serotonin Antagonists
• Ondansetron
• Cyclizine

Topics

• Adult
• Ambulatory Surgical Procedures
• Anesthesia Recovery Period
• Antiemetics (therapeutic use)
• Cyclizine (therapeutic use)
• Double-Blind Method
• Female
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Laparoscopy
• Ondansetron (therapeutic use)
• Postoperative Nausea and Vomiting (prevention & control)
• Serotonin Antagonists (therapeutic use)