Abstract | BACKGROUND: METHODS: Rats were operated with bile duct ligation (BDL). After 7 days, UCP2 mRNA levels were determined in liver and muscle. Simultaneously, insulin-stimulated glucose transport and glycogen synthesis in skeletal muscle were analyzed in vitro. RESULTS: The jaundiced rats lost more weight than pair-fed controls. UCP2 mRNA levels were increased 5-fold in liver but not in muscle in jaundiced rats compared to pair-fed controls. The jaundiced rats were hypoglycemic and hypoinsulinemic but demonstrated intact or enhanced insulin action on skeletal muscle glucose transport and glycogen synthesis in vitro. Muscle glycogen content was increased in the jaundiced rats. CONCLUSIONS:
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Authors | B Isaksson, C Rippe, R Simonoska, J E Holm, H Glaumann, R Segersvärd, J Larsson, C Erlanson-Albertsson, J Permert |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 37
Issue 1
Pg. 104-11
(Jan 2002)
ISSN: 0036-5521 [Print] England |
PMID | 11843026
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ion Channels
- Membrane Transport Proteins
- Mitochondrial Proteins
- Proteins
- Ucp2 protein, rat
- Uncoupling Agents
- Uncoupling Protein 2
- Glucose
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Topics |
- Animals
- Cholestasis
(genetics, metabolism)
- Disease Models, Animal
- Gene Expression
(genetics, physiology)
- Glucose
(genetics, metabolism)
- Insulin Resistance
(genetics, physiology)
- Ion Channels
- Liver
(metabolism)
- Male
- Membrane Transport Proteins
- Mitochondrial Proteins
- Muscle, Skeletal
(metabolism)
- Proteins
(genetics, metabolism)
- Rats
- Rats, Sprague-Dawley
- Uncoupling Agents
(metabolism)
- Uncoupling Protein 2
- Weight Loss
(genetics, physiology)
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