Vasopressin and epinephrine are equally effective for CPR in a rat asphyxia model.

Abstract

Epinephrine has been administered as a drug essential for cardiopulmonary resuscitation (CPR). Recently, vasopressin has been reported to be more effective than epinephrine for CPR in a ventricular fibrillation (VF) model. As a different myocardial pathology is speculated to exist between the VF model and the asphyxia model, we investigated whether vasopressin is also effective in a rat asphyxia model. Twenty-one Sprague-Dawley male rats were divided into three groups: vasopressin 0.8 U/kg (Vaso-Gr), epinephrine 0.05 mg/kg (Epi-Gr), and saline same volume as the other two drugs (Sal-Gr). Five minutes after suffocation induced by obstruction of the tracheal tube, CPR was performed using each drug. Although only one animal survived (17%) in the Sal-Gr, 6/7 (85%) survived in both Vaso-Gr and Epi-Gr (P<0.01). Vasopressin is as effective as epinephrine for CPR in asphyxia-induced rats.

• Authors: S Kono, H Bito, A Suzuki, Y Obata, H Igarashi, S Sato
• Journal: Resuscitation (Resuscitation) Vol. 52 Issue 2 Pg. 215-9 (Feb 2002) ISSN: 0300-9572 [Print] Ireland
• PMID: 11841890 (Publication Type: Journal Article)

Chemical References

• Vasoconstrictor Agents
• Vasopressins
• Epinephrine

Topics

• Animals
• Asphyxia (mortality, therapy)
• Cardiopulmonary Resuscitation
• Epinephrine (therapeutic use)
• Male
• Rats
• Rats, Sprague-Dawley
• Vasoconstrictor Agents (therapeutic use)
• Vasopressins (therapeutic use)