Abstract | PURPOSE: METHODS: The effects of CS-088 on intraocular pressure (IOP) were studied in 2 models of rabbit ocular hypertension. Experimental ocular hypertension was induced in albino rabbits by injecting alpha-chymotrypsin into the anterior chamber ( alpha-chymotrypsin rabbit). The effects of the single application of CS-088 were examined. Additionally, CS-088 was repeatedly administered over a period of 3 weeks to hereditary ocular hypertensive rabbits (buphthalmic rabbits, JWHR bu/bu) and the IOPs were monitored throughout the experiment. The effects of CS-088 on aqueous humor dynamics were also examined in normal rabbits. In this study, the methods of IOP recovery rate, two-level constant pressure perfusion and fluorescein-dextran perfusion were used respectively to determine the aqueous inflow, outflow facility and uveoscleral outflow (USF). RESULTS:
CS-088 at 1% and 2% significantly lowered the IOP in the alpha-chymotrypsin rabbits with a maximum IOP reduction of 10.1 mmHg. The maximum effect obtained with 2% CS-088 was no greater than that with 1% CS-088. In the buphthalmic rabbits, 2% CS-088 also lowered IOP significantly. Timolol was effective in both models. In the study on aqueous humor dynamics, a slight increase in USF (17%) was seen after a topical application of CS-088 whereas changes in aqueous inflow or outflow facility were not observed. CONCLUSIONS: Topical CS-088 can decrease IOP in rabbits. Despite the USF change, the ocular hypotensive mechanism by CS-088 was not fully determined.
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Authors | T Inoue, T Yokoyoma, Y Mori, Y Sasaki, T Hosokawa, H Yanagisawa, H Koike |
Journal | Current eye research
(Curr Eye Res)
Vol. 23
Issue 2
Pg. 133-8
(Aug 2001)
ISSN: 0271-3683 [Print] England |
PMID | 11840352
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Angiotensin Receptor Antagonists
- Imidazoles
- Ophthalmic Solutions
- Receptor, Angiotensin, Type 1
- Tetrazoles
- Timolol
- olmesartan
- Chymotrypsin
- alpha-chymotrypsin
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Topics |
- Administration, Topical
- Adrenergic beta-Antagonists
(administration & dosage, pharmacology)
- Angiotensin Receptor Antagonists
- Animals
- Aqueous Humor
(metabolism)
- Chymotrypsin
- Disease Models, Animal
- Imidazoles
(administration & dosage, pharmacology)
- Intraocular Pressure
(drug effects)
- Male
- Ocular Hypertension
(drug therapy, metabolism)
- Ophthalmic Solutions
- Rabbits
- Receptor, Angiotensin, Type 1
- Tetrazoles
(administration & dosage, pharmacology)
- Timolol
(administration & dosage, pharmacology)
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