Abstract | OBJECTIVE: METHODS: The p53 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism among 204 healthy controls and 91 patients with esophageal squamous cell carcinoma (ESCC). RESULTS: There was no significant difference between patients and controls with respect to allele frequency for the p53 Pro allele (0.480 versus 0.588, P=0.11); however, the Pro/Pro genotype of p53 among cases (39.6%) was significantly (P<0.05) more frequent than that among controls (21.1%). Subjects homozygous for the p53 Pro allele had a more than 2-fold increased risk of developing ESCC (OR=2.18; 95%CI=1.10-4.35, adjusted for age, sex, and smoking), whereas the Arg/Pro genotype was not associated with elevated risk of the cancer (adjusted OR=0.84; 95%CI=0.42-1.68). No interaction between smoking and Pro/Pro genotype was observed for risk of ESCC. CONCLUSION:
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Authors | Lei Zhang, Deyin Xing, Zugen He, Dongxin Lin |
Journal | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
(Zhonghua Yi Xue Yi Chuan Xue Za Zhi)
Vol. 19
Issue 1
Pg. 10-3
(Feb 2002)
ISSN: 1003-9406 [Print] China |
PMID | 11836677
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Codon
- Tumor Suppressor Protein p53
- Arginine
- Proline
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Topics |
- Alleles
- Arginine
(genetics)
- Asian People
(genetics)
- Carcinoma, Squamous Cell
(ethnology, genetics)
- Codon
(genetics)
- Confidence Intervals
- Esophageal Neoplasms
(ethnology, genetics)
- Genetic Predisposition to Disease
- Genotype
- Humans
- Odds Ratio
- Polymorphism, Genetic
- Proline
(genetics)
- Tumor Suppressor Protein p53
(genetics)
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