HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[p53 gene codon 72 polymorphism and susceptibility to esophageal squamous cell carcinoma in a Chinese population].

AbstractOBJECTIVE:
To investigate the relationship between p53 codon 72 polymorphism and susceptibility to esophageal squamous cell carcinoma in China.
METHODS:
The p53 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism among 204 healthy controls and 91 patients with esophageal squamous cell carcinoma (ESCC).
RESULTS:
There was no significant difference between patients and controls with respect to allele frequency for the p53 Pro allele (0.480 versus 0.588, P=0.11); however, the Pro/Pro genotype of p53 among cases (39.6%) was significantly (P<0.05) more frequent than that among controls (21.1%). Subjects homozygous for the p53 Pro allele had a more than 2-fold increased risk of developing ESCC (OR=2.18; 95%CI=1.10-4.35, adjusted for age, sex, and smoking), whereas the Arg/Pro genotype was not associated with elevated risk of the cancer (adjusted OR=0.84; 95%CI=0.42-1.68). No interaction between smoking and Pro/Pro genotype was observed for risk of ESCC.
CONCLUSION:
The p53 codon 72 polymorphism may play a role in susceptibility to esophageal carcinogenesis.
AuthorsLei Zhang, Deyin Xing, Zugen He, Dongxin Lin
JournalZhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 19 Issue 1 Pg. 10-3 (Feb 2002) ISSN: 1003-9406 [Print] China
PMID11836677 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Codon
  • Tumor Suppressor Protein p53
  • Arginine
  • Proline
Topics
  • Alleles
  • Arginine (genetics)
  • Asian People (genetics)
  • Carcinoma, Squamous Cell (ethnology, genetics)
  • Codon (genetics)
  • Confidence Intervals
  • Esophageal Neoplasms (ethnology, genetics)
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Odds Ratio
  • Polymorphism, Genetic
  • Proline (genetics)
  • Tumor Suppressor Protein p53 (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: