[An experimental study on effect of methazolamide on decreasing intraocular pressure in rabbits].

Abstract

OBJECTIVE:

To study the therapeutic effect of methazolamide on glaucoma.

METHODS:

Various doses of methazolamide were orally administered in rabbits, their effects on high intraocular pressures and on recovery of low intraocular pressures were observed.

RESULTS:

The high intraocular pressures were significantly decreased and the maintenance of low intraocular pressure was significantly prolonged by the oral administration of 40, 20, 10 mg/kg of methazolamide. A dose-effect relationship that is the reduction of intraocular pressure increases with the increase of the dosage administration of methazolamide could be observed.

CONCLUSION:

This study indicates that methazolamide might play an effective therapeutic role in glaucoma.

• Authors: H Xu, Q Yao, G Zhou
• Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology (Zhonghua Yan Ke Za Zhi) Vol. 35 Issue 1 Pg. 55-7 (Jan 1999) ISSN: 0412-4081 [Print] China
• PMID: 11835778 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbonic Anhydrase Inhibitors
• Methazolamide

Topics

• Animals
• Carbonic Anhydrase Inhibitors (administration & dosage)
• Dose-Response Relationship, Drug
• Glaucoma (drug therapy)
• Intraocular Pressure (drug effects)
• Methazolamide (administration & dosage)
• Ocular Hypotension (drug therapy)
• Rabbits