Increased carotid artery intima-media thickness in subjects with primary hypoalphalipoproteinemia.

Abstract

The plasma concentration of high-density lipoprotein cholesterol (HDL-C) is inversely correlated with the incidence of atherosclerotic vascular events. In the present study, we evaluated pre-intrusive atherosclerosis in subjects with plasma HDL-C at the extremities of normal distribution. Fifty-five subjects with primary hypoalphalipoproteinemia (HypoALP) or hyperalphalipoproteinemia (HyperALP) were compared with fifty-five control subjects with average HDL-C levels, matched for sex, age, and plasma cholesterol. The average and maximal intima-media thicknesses (Avg-IMT and Max-IMT) of 48 carotid segments for each subject were approximately 40% greater in HypoALP than in control subjects (0.94 +/- 0.06 versus 0.69 +/- 0.04 mm, P=0.004, and 1.86 +/- 0.16 versus 1.35 +/- 0.10 mm, P=0.025, respectively). The IMT values in HyperALP subjects (Avg-IMT, 0.71 +/- 0.04 and Max-IMT, 1.38 +/- 0.14 mm) were the same as in controls. In a large cohort of hyperlipidemic subjects (n=559), significantly greater Avg-IMT and Max-IMT were found in subjects belonging to the first HDL-C quintile (<42 mg/dL) than in all the others. The measurement of carotid IMT in cases with HypoALP and HyperALP, and in a large series of hyperlipidemic patients, thus indicates that a low HDL-C is associated with significant pre-intrusive atherosclerosis, whereas a HDL-C level above average values does not lead to a further reduction of arterial wall thickening.

• Authors: Damiano Baldassarre, Mauro Amato, Linda Pustina, Elena Tremoli, Cesare R Sirtori, Laura Calabresi, Guido Franceschini
• Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 22 Issue 2 Pg. 317-22 (Feb 01 2002) ISSN: 1524-4636 [Electronic] United States
• PMID: 11834535 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL

Topics

• Carotid Arteries (diagnostic imaging)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Female
• Humans
• Hyperlipidemias (blood, diagnostic imaging)
• Male
• Middle Aged
• Regression Analysis
• Sex Factors
• Tangier Disease (blood, diagnostic imaging)
• Tunica Intima (diagnostic imaging)
• Tunica Media (diagnostic imaging)
• Ultrasonography