Abstract | BACKGROUND: METHODS: A retrospective chart review was performed for 100 consecutive patients with either primary PHT (48%) or secondary PHT (52%) transplants since 1989. Living recipients were contacted to confirm health and functional status. RESULTS: Fifty-five adult and 45 pediatric patients underwent 51 bilateral lung transplants, 39 single lung transplants, and 10 heart-lung transplants. Mean age was 23.7 years (range, 1.2 months to 54.8 years) and mean pre-transplant New York Heart Association class was 3.2. Pre-transplant hemodynamics revealed a mean right atrial pressure of 9.6+/-5.4 mm Hg and mean pulmonary artery pressure of 64+/-14.4 mm Hg. Hospital mortality was 17% with early death predominantly because of graft failure and infection. With an average follow-up of 5.0 years, 1- and 5-year actuarial survival was 75% and 57%, respectively. Mean pulmonary artery pressure on follow-up catheterization was 22+/-6.0 mm Hg, and mean follow-up New York Heart Association class was 1.3 (p < 0.001 for both compared with pre-transplant). Diagnosis and type of transplant did not confer a significant difference in survival between groups. CONCLUSIONS: Whereas lung or heart-lung transplant for PHT is associated with higher early mortality than other pulmonary disease entities, it provides similar long-term outcomes with dramatic improvement in both quality of life and physiologic aspects.
|
Authors | Eric N Mendeloff, Bryan F Meyers, Thoralf M Sundt, Tracey J Guthrie, Stuart C Sweet, Maite de la Morena, Steve Shapiro, David T Balzer, Elbert P Trulock, John P Lynch, Michael K Pasque, Joel D Cooper, Charles B Huddleston, G Alexander Patterson |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 73
Issue 1
Pg. 209-17; discussion 217-9
(Jan 2002)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 11834012
(Publication Type: Journal Article)
|
Chemical References |
- Immunosuppressive Agents
- Cyclosporine
|
Topics |
- Adolescent
- Adult
- Bronchiolitis Obliterans
(surgery)
- Child
- Child, Preschool
- Cyclosporine
(administration & dosage)
- Female
- Hemodynamics
- Humans
- Hypertension, Pulmonary
(surgery)
- Immunosuppressive Agents
(administration & dosage)
- Infant
- Lung Transplantation
(methods, mortality)
- Male
- Middle Aged
- Retrospective Studies
- Survival Analysis
|