Cardiovascular properties of yangambin, a lignan isolated from Brazilian plants.

Abstract

Yangambin was initially selected from a number of lignans isolated from Brazilian plants for its ability to antagonize Platelet-Activating Factor (PAF, 1-O-hexadecyl-2-acetyl- sn-glyceryl-3-phosphorylcholine)-induced biological effects. Subsequently it was shown that, besides its antagonistic properties at PAF receptors, yangambin also prevents the cardiovascular collapse observed during anaphylactic and endotoxic/septic shocks, as well as the vascular and cardiac hyporesponsiveness to catecholamines in endotoxic shock. It is suggested that this naturally occurring compound could be of potential interest in the adjunctive management of the above mentioned pathologies. In the present article, we review the main studies investigating the pharmacological properties of yangambin related to the cardiovascular function.

• Authors: E Tibiriçá
• Journal: Cardiovascular drug reviews (Cardiovasc Drug Rev) Vol. 19 Issue 4 Pg. 313-28 ( 2001) ISSN: 0897-5957 [Print] United States
• PMID: 11830750 (Publication Type: Journal Article, Review)

Chemical References

• Cardiovascular Agents
• Furans
• Lignans
• Plant Extracts
• Platelet Activating Factor
• Platelet Aggregation Inhibitors
• Platelet Membrane Glycoproteins
• Receptors, Cell Surface
• Receptors, G-Protein-Coupled
• platelet activating factor receptor
• epiyangambin

Topics

• Anaphylaxis (drug therapy, metabolism, physiopathology)
• Animals
• Blood Platelets (metabolism)
• Cardiovascular Agents (chemistry, pharmacology, therapeutic use)
• Furans (chemistry, pharmacology, therapeutic use)
• Hemodynamics (drug effects)
• In Vitro Techniques
• Lignans (chemistry, pharmacology, therapeutic use)
• Plant Extracts (chemistry, pharmacology, therapeutic use)
• Platelet Activating Factor (physiology)
• Platelet Aggregation Inhibitors (chemistry, pharmacology, therapeutic use)
• Platelet Membrane Glycoproteins (antagonists & inhibitors, metabolism)
• Receptors, Cell Surface
• Receptors, G-Protein-Coupled
• Shock, Septic (drug therapy, metabolism, physiopathology)
• Stereoisomerism