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Clinical evaluation of anorganic bovine bone xenograft with a bioabsorbable collagen barrier in the treatment of molar furcation defects.

Abstract
The purpose of this study was to compare Bio-Oss (BO), an anorganic bovine bone xenograft, in combination with Bio-Gide (BG), a bioabsorbable collagen barrier, to open-flap debridement (OFD) surgery in human mandibular Class II furcation defects. A total of 31 furcations (18 treatment, 13 control) in 21 patients were treated. There was a statistically significant improvement in most clinical indices for the BO/BG group, with minimal improvement noted for the OFD group. Vertical probing depth reduction of 2.0 mm and horizontal probing depth reduction of 2.2 mm were noted for the BO/BG group, with 0.3 mm and 0.2 mm reductions, respectively, noted for OFD. Hard tissue measurements showed 2.0 mm of vertical furcation bone fill for BO/BG and 0.5 mm for OFD. The BO/BG group had 3.0 mm of horizontal furcation bone fill, and the OFD group had 0.9 mm. The BO/BG group had a defect resolution of 82.7%; 42.5% was noted for the OFD group. There was a statistically significant difference between BO/BG and OFD in all soft and hard tissue measurements with the exception of attachment level, recession, and alveolar crest resorption.
AuthorsB E Houser, J T Mellonig, M A Brunsvold, D L Cochran, R M Meffert, M E Alder
JournalThe International journal of periodontics & restorative dentistry (Int J Periodontics Restorative Dent) Vol. 21 Issue 2 Pg. 161-9 (Apr 2001) ISSN: 0198-7569 [Print] United States
PMID11829390 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Bio-Gide
  • Bio-Oss
  • Bone Substitutes
  • Membranes, Artificial
  • Minerals
  • Collagen
Topics
  • Absorbable Implants
  • Alveolar Process (pathology)
  • Analysis of Variance
  • Animals
  • Bone Matrix (transplantation)
  • Bone Regeneration (physiology)
  • Bone Substitutes (therapeutic use)
  • Cattle
  • Collagen (therapeutic use)
  • Debridement
  • Female
  • Follow-Up Studies
  • Furcation Defects (classification, pathology, surgery)
  • Gingival Recession (pathology, surgery)
  • Humans
  • Male
  • Mandible (pathology, surgery)
  • Membranes, Artificial
  • Middle Aged
  • Minerals (therapeutic use)
  • Molar (pathology, surgery)
  • Periodontal Attachment Loss (pathology, surgery)
  • Single-Blind Method
  • Statistics as Topic
  • Surgical Flaps
  • Transplantation, Heterologous
  • Treatment Outcome

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