Effect of influenza vaccination on serum clozapine and its main metabolite concentrations in patients with schizophrenia.

Abstract

OBJECTIVE:

To study the effect of influenza vaccine on serum clozapine, N-desmethylclozapine and clozapine-N-oxide steady-state concentrations in patients with schizophrenia.

METHODS:

This was an open-label study in 14 schizophrenic inpatients (with 2 drop-outs) using clozapine. Serum trough concentrations of clozapine. N-desmethylclozapine and clozapine-N-oxide, as well as the concentration of c-reactive protein (CRP), were measured immediately before conventional trivalent influenza vaccination and 2, 4, 7 and 14 days after the vaccination.

RESULTS:

Influenza vaccination had no significant effect on serum concentrations of clozapine, N-desmethylclozapine or clozapine-N-oxide. No changes in the clinical effects of clozapine were observed after vaccination. Influenza vaccination did not increase CRP. However, two drop-out patients who developed upper respiratory and abdominal symptoms had increased and elevated serum concentrations of clozapine, compared with the baseline.

CONCLUSIONS:

Influenza vaccination using conventional trivalent influenza vaccine does not affect serum concentrations of clozapine or its main metabolites. However, an infection-related increase in CRP may be associated with increased serum concentration of clozapine.

• Authors: K Raaska, V Raitasuo, P J Neuvonen
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 57 Issue 10 Pg. 705-8 (Dec 2001) ISSN: 0031-6970 [Print] Germany
• PMID: 11829199 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Influenza Vaccines
• norclozapine
• C-Reactive Protein
• Clozapine
• clozapine N-oxide

Topics

• Adult
• Antipsychotic Agents (blood, pharmacokinetics, therapeutic use)
• C-Reactive Protein (metabolism)
• Clozapine (analogs & derivatives, blood, pharmacokinetics, therapeutic use)
• Drug Interactions
• Female
• Humans
• Influenza Vaccines (pharmacology)
• Male
• Middle Aged
• Schizophrenia (blood, drug therapy)
• Vaccination