Abstract | OBJECTIVE: METHODS: RESULTS:
Influenza vaccination had no significant effect on serum concentrations of clozapine, N-desmethylclozapine or clozapine-N-oxide. No changes in the clinical effects of clozapine were observed after vaccination. Influenza vaccination did not increase CRP. However, two drop-out patients who developed upper respiratory and abdominal symptoms had increased and elevated serum concentrations of clozapine, compared with the baseline. CONCLUSIONS:
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Authors | K Raaska, V Raitasuo, P J Neuvonen |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 57
Issue 10
Pg. 705-8
(Dec 2001)
ISSN: 0031-6970 [Print] Germany |
PMID | 11829199
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Influenza Vaccines
- norclozapine
- C-Reactive Protein
- Clozapine
- clozapine N-oxide
|
Topics |
- Adult
- Antipsychotic Agents
(blood, pharmacokinetics, therapeutic use)
- C-Reactive Protein
(metabolism)
- Clozapine
(analogs & derivatives, blood, pharmacokinetics, therapeutic use)
- Drug Interactions
- Female
- Humans
- Influenza Vaccines
(pharmacology)
- Male
- Middle Aged
- Schizophrenia
(blood, drug therapy)
- Vaccination
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