Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L.

Abstract

The acute LD50s of ferulenol were determined in albino mice by single po or ip as 2,100 and 319 mg/kg bw, respectively. Ferulenol had a higher LD50 compared to warfarin and thus has a lower acute toxicity. Three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages similar to those described in ferulosys and anti-vitamin K experimental poisonings. Male mice were more sensitive to intoxication by ferulenol than were females.

• Authors: O Fraigui, D Lamnaouer, M Y A Faouzi
• Journal: Veterinary and human toxicology (Vet Hum Toxicol) Vol. 44 Issue 1 Pg. 5-7 (Feb 2002) ISSN: 0145-6296 [Print] United States
• PMID: 11828999 (Publication Type: Journal Article)

Chemical References

• Coumarins
• ferulenol

Topics

• Administration, Oral
• Animals
• Coumarins (administration & dosage, toxicity)
• Dose-Response Relationship, Drug
• Female
• Injections, Intraperitoneal
• Lethal Dose 50
• Male
• Mice