Abstract |
The antithrombotic and thrombolytic activities of Agkisacutacin (Agk), a component isolated from Agkistrodon acutus, were determined in vitro and in vivo. The models employed included Chandler's model, arterio-venous shunt model and pulmonary embolus model. The effects of Agkisacutacin on coagulation, plasma fibrinogen and platelet aggregation induced by collagen, adenosine diphosphate ( ADP) and thrombin were also investigated. The results showed that Agkisacutacin can significantly inhibit thrombus formation in Chandler's and arterio-venous shunt models, and accelerate thrombolysis of pulmonary emboli in rats. The data suggested that Agkisacutacin possessed antithrombotic and thrombolytic activities. Agkisacutacin was also partial characterized.
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Authors | S Li, H Ji, X Cheng, B X Li, T B Ng |
Journal | General pharmacology
(Gen Pharmacol)
Vol. 35
Issue 4
Pg. 179-87
(Oct 2000)
ISSN: 0306-3623 [Print] England |
PMID | 11827724
(Publication Type: Journal Article)
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Chemical References |
- Crotalid Venoms
- Fibrinolytic Agents
- agkisacutacin
- Fibrinogen
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Topics |
- Animals
- Crotalid Venoms
(chemistry, isolation & purification, pharmacology)
- Fibrinogen
(metabolism)
- Fibrinolytic Agents
(pharmacology)
- Male
- Platelet Aggregation
(drug effects)
- Pulmonary Embolism
(drug therapy)
- Rats
- Rats, Sprague-Dawley
- Structure-Activity Relationship
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