Pyloricidins, novel anti-helicobacterpylori antibiotics produced by Bacillus sp. I. Taxonomy, fermentation and biological activity.

Abstract

Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A1, A2, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H. pylori infection as a single agent.

• Authors: M Nakao, K Miyagaw, Y Nakano, T Sakane, M Tada, O Nishimura, M Fujino
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 54 Issue 11 Pg. 926-33 (Nov 2001) ISSN: 0021-8820 [Print] England
• PMID: 11827035 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Peptides
• Metronidazole
• Amoxicillin
• Clarithromycin

Topics

• Amoxicillin (pharmacology)
• Animals
• Anti-Bacterial Agents (isolation & purification, pharmacology)
• Bacillus (chemistry, classification, metabolism)
• Biological Assay
• Clarithromycin (pharmacology)
• Fermentation
• Gerbillinae
• Helicobacter Infections (drug therapy)
• Helicobacter pylori (drug effects, growth & development)
• Humans
• Metronidazole (pharmacology)
• Microbial Sensitivity Tests
• Peptides